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Mutagenesis in Single-Cells and Evolution (MuSE) 

The generation of variation in the DNA sequence of genomes is a prerequisite for adaptation. Our work complements existing knowledge in the field by addressing the generation of genetic variation and its consequences at the single-cell level, in phages and bacteria.

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Our approach is interdisciplinary and involves the development of new tools that combine genetics, molecular biology, fluorescent microscopy, optogenetics, microfluidics, image analysis  and modelling.

Our team is growing! 
We have funding to take on new team members across various positions. 

Group photograph of the researchers of the Mutagenesis in Single-Cell and Evolution (MuSE) Lab standing in front of the MICALIS building in Jouy En Josas, France.

Our Team in Feburary 2023 

Notable Publications


C Enrico Bena, J Ollion, M De Paepe, M Ventroux, L Robert , M Elez

Real-time monitoring of replication errors' fate reveals the origin and dynamics of spontaneous mutations

Real-time monitoring of replication errors' fate reveals the origin and dynamics of spontaneous mutations

2024

Nature Communications

10.1038/s41467-024-46950-0

J K Cornuault, E Moncaut, V Loux, A Mathieu, H Sokol, M A Petit, M De Paepe

The enemy from within: a prophage of Roseburia intestinalis systematically turns lytic in the mouse gut, driving bacterial adaptation by CRISPR spacer acquisition

The enemy from within: a prophage of Roseburia intestinalis systematically turns lytic in the mouse gut, driving bacterial adaptation by CRISPR spacer acquisition

2020

The ISME Journal

10.1038/s41396-019-0566-x

J Ollion, M Elez, L Robert

High-throughput detection and tracking of cells and intracellular spots in mother machine experiments

High-throughput detection and tracking of cells and intracellular spots in mother machine experiments

2019

Nature Protocols

10.1038/s41596-019-0216-9
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